Designer babies – fact or fiction?
In vitro fertilisation has helped many overcome difficulties with having children. However, it raises a number of ethical issues, one of which is the ability to select for particular traits or diseases using a technique called preimplantation genetic diagnosis (PGD).
PGD was first used in Britain in 1989 to test embryos fertilised in vitro for inherited diseases such as cystic fibrosis, Huntingdon’s disease, and Fragile-X syndrome or for diseases causes by abnormal chromosome structure, such as Down’s Syndrome. After testing, unaffected embryos are transferred into the mother’s uterus.
Previously, the only testing option for couples at risk of passing an inherited condition to their children was by sampling foetal cells from the placenta or amniotic fluid. If a foetus was found to be affected, parents would then have to decide whether to proceed with the pregnancy, or have an abortion.
How is PGD done?
During in vitro fertilisation (IVF), eggs are removed from a woman’s ovaries and fertilised with sperm. The fertilised eggs undergo normal mitotic cell division in the lab until they have eight cells. At this stage, one or two of these cells are removed. DNA from the cells is extracted and tested for the presence of genetic disorders.
The genetic contents of the cells are tested using polymerase chain reaction (PCR) or fluorescence in situ hybridisation (FISH). PCR is used to look for single gene abnormalities, whereas FISH is used to look for abnormal chromosomes.
Embryos that are not at risk of disease are then transferred into the woman’s uterus where they may implant and develop. The removal of cells for testing does not affect the development of the embryo, as these cells are replaced as the embryo’s cells continue to divide and grow.
When is PGD used?
PGD is an expensive procedure and is normally used to test embryos of couples who have a high risk of passing an inherited condition to their children. If both parents have a family history of cystic fibrosis, there is a chance that they could be carriers of the disease and have children with cystic fibrosis, even if neither of them actually has it.
PGD has been used by couples to select an embryo that will make a compatible donor of stem cells to treat a sick sibling.
PGD can also be used to test for other traits, such as gender or deafness, but these tests raise a number of ethical issues and are not permitted in most countries.
Ethical issues of PGD
The IVF procedure creates a surplus of embryos, which are usually destroyed. There are many people who believe this is unethical. PGD gives parents the ability to select against particular combinations of their genes (that could occur naturally) by choosing which embryos are implanted and which are destroyed. However, others believe PGD is preferable to aborting a foetus at a later stage in pregnancy.
Some people fear that PGD will lead to selecting for particular traits, such as sex, hair colour or behaviour, and will allow people to make ‘designer babies’. However, most of these traits are the result of the action of more than one gene, and it is unlikely that people will be able to select for complex traits like these.
PGD in New Zealand
Guidelines for using PGD in New Zealand are available from the Advisory Committee on Assisted Reproductive Technology (ACART). These guidelines were developed in March 2005 after consultation with the New Zealand people.
In New Zealand, PGD may be used to test for inherited diseases and chromosomal abnormalities. PGD may also be used to match embryo tissue for stem cell therapy of a sibling with approval from the Ethics Committee on Assisted Reproductive Technology (ECART). In New Zealand, PGD cannot be used:
- for social reasons, including sex selection
- to alter the genetic constitution of an embryo
- to select embryos with a genetic impairment seen in a parent.
- 15 November 2007